Hughey M C, Yost R L, Robinson J D, Harman E M
Drug Intell Clin Pharm. 1982 Apr;16(4):301-5. doi: 10.1177/106002808201600405.
A study was designed to evaluate the validity of the dosage guidelines for theophylline recommended by Hendeles and Weinberger. A total of seven asthmatic smokers and non-smokers were entered and studied. Theophylline serum concentrations were determined prior to the start of therapy and at intervals following initiation of an infusion. The mean theophylline concentration attained for all subjects was 10 micrograms/ml, however, five of the six patients completing the study did not achieve the predicted serum theophylline concentration. Further study of higher dosage designed to achieve a concentration of 12 micrograms/ml is suggested.
一项研究旨在评估亨德莱斯和温伯格推荐的茶碱剂量指南的有效性。总共纳入并研究了7名哮喘吸烟者和非吸烟者。在治疗开始前以及开始输注后的不同时间间隔测定血清茶碱浓度。所有受试者达到的平均茶碱浓度为10微克/毫升，然而，完成研究的6名患者中有5名未达到预测的血清茶碱浓度。建议进一步研究更高剂量以达到12微克/毫升的浓度。
