Robinson J D, Boysen P G, Lupkiewicz S M, Krischer J P, Ariet M
Drug Intell Clin Pharm. 1982 Oct;16(10):752-8. doi: 10.1177/106002808201601009.
Intravenous aminophylline was administered to 13 subjects (6 normal, 7 with chronic obstructive pulmonary disease), and multiple blood specimens were drawn over an 8-hour period for theophylline analysis. Half of the samples were obtained during the distribution phase of the drug and the remainder during the elimination phase. These data were entered into a computer program that both calculates and graphically displays individual two-compartment pharmacokinetic data, and recommends a dosing regimen. Analysis of these data demonstrates wide variability in the theophylline volume of distribution, half-life, and predicted dosage regimen. Dosage regimens can be individualized by obtaining two specimens for theophylline analysis during the elimination phase after intravenous administration of the drug; these regimens correlate extremely well (r2 = 0.95) with those designed using all the data points.
对13名受试者（6名正常人，7名慢性阻塞性肺疾病患者）静脉注射氨茶碱，并在8小时内采集多份血样进行茶碱分析。一半样本在药物分布阶段采集，其余样本在消除阶段采集。这些数据被输入一个计算机程序，该程序既能计算并以图形方式显示个体双室药代动力学数据，还能推荐给药方案。对这些数据的分析表明，茶碱的分布容积、半衰期和预测给药方案存在很大差异。给药方案可以通过在静脉给药后的消除阶段采集两份茶碱分析样本来个体化；这些方案与使用所有数据点设计的方案相关性非常好（r2 = 0.95）。
