Alexandersson R, Hedenstierna G
Int Arch Occup Environ Health. 1982 Feb;49(3-4):275-80. doi: 10.1007/BF00377936.
Symptoms and pulmonary function were evaluated in subjects exposed to trichlorophenol. Symptoms from upper airways and chest were more common among those exposed than in control subjects (60% and 10%, respectively) Significantly reduced forced expired flow at 75% of vital capacity [exposed: 5.721/s (5.08-6.85), mean and range; reference: 6.451/s (5.77-8.40), P less than 0.05] and increased closing volume [exposed: 25.2% (19.5-36.0), reference: 17.1% (12.0-23.5), P less than 0.01] were measured while other spirometric variables and the transfer factor of the lung for CO were normal. Increased elastic recoil pressure of the lung and signs of lung tissue engagement in X ray were noticed in two subjects. Blood and liver tests were normal. The findings suggest an irritating effect on the lung by trichlorophenol, and it cannot be excluded that long-term exposure may produce pulmonary fibrosis.
对接触三氯苯酚的受试者的症状和肺功能进行了评估。与对照组相比，接触者上呼吸道和胸部症状更为常见（分别为60%和10%）。肺活量75%时用力呼气流量显著降低[接触组：5.72升/秒（5.08 - 6.85），均值和范围；参照组：6.45升/秒（5.77 - 8.40），P<0.05]，闭合气量增加[接触组：25.2%（19.5 - 36.0），参照组：17.1%（12.0 - 23.5），P<0.01]，而其他肺量计变量和肺一氧化碳转运因子正常。两名受试者出现肺弹性回缩压升高和X线显示的肺组织受累迹象。血液和肝脏检查正常。这些发现提示三氯苯酚对肺有刺激作用，不能排除长期接触可能导致肺纤维化。
