Treatment of acute uncomplicated urinary tract infections by cephalexin, with special reference to the antibody-coated bacteria.

In 68 college-age females with acute uncomplicated urinary tract infections (UTI), ACB testing revealed that 36.8% of the infections were localized in the kidney and 63.2% in the urinary bladder. Sixty-two patients who completed 10 days of therapy with cephalexin showed a clinical and bacteriologic cure on the last day of therapy. Ninety-seven percent of patients were free of UTI at 1 week post therapy. Cephalexin appeared to be equally effective in treatment of both ACB-positive and ACB-negative infections. Antibody-coated bacteria did not correlate with symptoms, response to therapy, or rate of recurrences.