单剂量头孢曲松与多剂量甲氧苄啶-磺胺甲恶唑治疗急性尿路感染的比较
Single-dose ceftriaxone versus multiple-dose trimethoprim-sulfamethoxazole in the treatment of acute urinary tract infections.
作者信息
Iravani A, Richard G A
出版信息
Antimicrob Agents Chemother. 1985 Feb;27(2):158-61. doi: 10.1128/AAC.27.2.158.
Abstract
Fifty-four college women with symptoms of lower urinary tract infections were randomly treated, 25 with 500 mg of ceftriaxone in a single intramuscular dose and 29 with 160 mg of trimethoprim-800 mg of sulfamethoxazole orally twice daily for 7 days. At 1 week after treatment, 23 patients (92%) in the ceftriaxone group and 28 patients (96%) in the trimethoprim-sulfamethoxazole group were cured. Responses of the patients with positive or negative antibody-coated bacteria tests were not significantly different. Four patients (16%) in the ceftriaxone group developed diarrhea and malaise. One patient (4%) in the trimethoprim-sulfamethoxazole group had medication discontinued because of headaches. Leukopenia was found in one patient (4%) in the ceftriaxone group and four patients (14%) in the trimethoprim-sulfamethoxazole group.
摘要
54名有下尿路感染症状的大学女性被随机分组治疗，25名接受单次肌内注射500毫克头孢曲松，29名口服160毫克甲氧苄啶-800毫克磺胺甲恶唑，每日两次，共7天。治疗1周后，头孢曲松组23例患者（92%）治愈，甲氧苄啶-磺胺甲恶唑组28例患者（96%）治愈。抗体包裹细菌检测呈阳性或阴性的患者的反应无显著差异。头孢曲松组4例患者（16%）出现腹泻和不适。甲氧苄啶-磺胺甲恶唑组1例患者（4%）因头痛停药。头孢曲松组1例患者（4%）出现白细胞减少，甲氧苄啶-磺胺甲恶唑组4例患者（14%）出现白细胞减少。
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