Bhattacharya J, Nanjo S, Staub N C
J Appl Physiol Respir Environ Exerc Physiol. 1982 Mar;52(3):634-7. doi: 10.1152/jappl.1982.52.3.634.
We punctured subpleural microvessels in 19 isolated blood-perfused dog lung lobes to determine the effect of 5-hydroxytryptamine (5-HT) on the pulmonary microvascular pressure profile. Maintaining lobe airway pressure at 6 cmH2O and lobe venous pressure at 10 cmH2O we infused saline alone (10 microliter/min) in 10 control lobes and 5-HT in saline solution (100--150 micrograms/min) in 9 lobes. We measured pressures in subpleural microvessels using micropipettes connected to a servo-null system. The 5-HT infusion doubled lobar vascular resistance. In all microvessels upstream from the 150-micrometer venules, pressure was higher than in the control lobes. In contrast to the control lobes, pressure dropped markedly from the lobar artery to the 50-micrometer arterioles and from the venous capillaries to the 50-micrometer venules. We conclude that 5-HT not only constricted arterioles, but also raised lung microvascular pressure by constricting postcapillary venules.
我们在19个单独的血液灌注犬肺叶中穿刺胸膜下微血管，以确定5-羟色胺（5-HT）对肺微血管压力分布的影响。将肺叶气道压力维持在6 cmH₂O，肺叶静脉压力维持在10 cmH₂O，我们在10个对照肺叶中仅输注生理盐水（10微升/分钟），在9个肺叶中输注含5-HT的生理盐水溶液（100 - 150微克/分钟）。我们使用连接到伺服零位系统的微量移液器测量胸膜下微血管的压力。输注5-HT使肺叶血管阻力增加一倍。在150微米小静脉上游的所有微血管中，压力均高于对照肺叶。与对照肺叶相比，压力从肺叶动脉到50微米小动脉以及从静脉毛细血管到50微米小静脉均显著下降。我们得出结论，5-HT不仅使小动脉收缩，还通过收缩毛细血管后小静脉升高了肺微血管压力。
