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The true hydrophobicity of microsomal cytochrome P-450 in the rat. Size dependence of the free energy of binding of a series of hydrocarbon substrates from the aqueous phase to the enzyme and to the membrane as derived from spectral binding data.

作者信息

Backes W L, Hogaboom M, Canady W J

出版信息

J Biol Chem. 1982 Apr 25;257(8):4063-70.

PMID:7068626
Abstract
摘要

相似文献

1
The true hydrophobicity of microsomal cytochrome P-450 in the rat. Size dependence of the free energy of binding of a series of hydrocarbon substrates from the aqueous phase to the enzyme and to the membrane as derived from spectral binding data.大鼠微粒体细胞色素P-450的真实疏水性。根据光谱结合数据得出的一系列烃类底物从水相到酶及到膜的结合自由能的尺寸依赖性。
J Biol Chem. 1982 Apr 25;257(8):4063-70.
2
Competition between hydrocarbon and barbiturate for spectral binding to hepatic cytochrome P-450. Inferences concerning spin state of the enzyme.烃类与巴比妥酸盐在肝脏细胞色素P-450光谱结合上的竞争。关于该酶自旋状态的推断。
J Biol Chem. 1984 Aug 25;259(16):10092-9.
3
[Multiphasic character of the kinetics of cytochrome P-450 destruction in microsomal LM2- and LM4-forms in the reaction with cumene hydroperoxide].[与氢过氧化异丙苯反应时微粒体LM2和LM4形式中细胞色素P-450破坏动力学的多相特征]
Biofizika. 1980 Jan-Feb;25(1):75-81.
4
Comparative MO-QSAR studies in various species including man.在包括人类在内的各种物种中的比较分子轨道定量构效关系（MO-QSAR）研究。
Chem Biol Interact. 1996 Mar 25;100(2):187-201. doi: 10.1016/0009-2797(96)03699-x.
5
The increasing and decreasing effects of aromatic hydrocarbon solvents on pulmonary and hepatic cytochrome P-450 in the rat.
Pharmacol Toxicol. 1987 Apr;60(4):288-93. doi: 10.1111/j.1600-0773.1987.tb01754.x.
6
The oxidation of cyclopropyl benzene by rat liver microsomal cytochrome P-450: an unusual triple oxidation of a substrate.大鼠肝脏微粒体细胞色素P-450对环丙基苯的氧化：底物的一种不寻常的三重氧化。
FEBS Lett. 1982 Aug 23;145(2):179-81. doi: 10.1016/0014-5793(82)80162-2.
7
Aromatic hydrocarbon binding to cytochrome P450 and other enzyme binding sites: are hydrophobic compounds drawn into the active site or pushed from the aqueous phase?芳烃与细胞色素P450及其他酶结合位点的结合：疏水性化合物是被吸入活性位点还是从水相中被推开？
Arch Biochem Biophys. 1993 Jul;304(1):27-37. doi: 10.1006/abbi.1993.1317.
8
The interaction of hepatic cytochrome P-450 with organic solvents. The effect of organic solvents on apparent spectral binding constants for hydrocarbon substrates.肝细胞色素P - 450与有机溶剂的相互作用。有机溶剂对烃类底物表观光谱结合常数的影响。
J Biol Chem. 1981 Jul 25;256(14):7213-27.
9
[Kinetics of formation of the enzyme-substrate complexes of cytochrome P-450 in rat liver microsomes].
Biokhimiia. 1980 Mar;45(3):474-82.
10
Reduction kinetics of purified rat liver cytochrome P-450. Evidence for a sequential reaction mechanism dependent on the hemoprotein spin state.纯化大鼠肝脏细胞色素P-450的还原动力学。依赖于血红素蛋白自旋状态的顺序反应机制的证据。
Biochemistry. 1984 Sep 25;23(20):4526-33. doi: 10.1021/bi00315a004.

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Cellular uptake and intracellular localization of benzo(a)pyrene by digital fluorescence imaging microscopy.通过数字荧光成像显微镜观察苯并(a)芘的细胞摄取及细胞内定位
J Cell Biol. 1985 Apr;100(4):1295-308. doi: 10.1083/jcb.100.4.1295.
2
Liposomes as carriers of poorly water-soluble substrates: linear modelling of membrane systems with catalytic or binding sites of different facedness. Significance of experimental membrane partition coefficients and of kinetic and equilibrium parameters.脂质体作为难溶性底物的载体：具有不同朝向催化或结合位点的膜系统的线性建模。实验性膜分配系数以及动力学和平衡参数的意义。
Biochem J. 1988 Aug 15;254(1):101-8. doi: 10.1042/bj2540101.
3
Interaction of 7-n-alkoxycoumarins with cytochrome P-450(2) and their partitioning into liposomal membranes. Assessment of methods for determination of membrane partition coefficients.
7-正烷氧基香豆素与细胞色素P-450(2)的相互作用及其在脂质体膜中的分配。膜分配系数测定方法的评估。
Biochem J. 1992 Jun 1;284 ( Pt 2)(Pt 2):483-90. doi: 10.1042/bj2840483.