Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, United States.
Brain Res. 2023 Jan 15;1799:148177. doi: 10.1016/j.brainres.2022.148177. Epub 2022 Nov 26.
Taste neophobia, the rejection of novel tastes or foods, involves an interplay of various brain regions encompassing areas within the central gustatory system, as well as nuclei serving other functions. Previous findings, utilising c-Fos imaging, identified several brain regions which displayed higher activity after ingestion of a novel taste as compared to a familiar taste. The present study extends this analysis to include additional regions suspected of contributing to the neurocircuitry involved in evoking taste neophobia. Our data show increased c-Fos expression in the basolateral amygdala, central nucleus of the amygdala, gustatory portion of the thalamus, gustatory portion of the insular cortex and the medial and lateral regions of the parabrachial nucleus. These results confirm the contribution of areas previously identified as active during ingestion of novel tastes and expose additional areas that express elevated levels of c-Fos under these conditions, thus adding to the neural network involved in the detection and initial processing of taste novelty.
味觉厌恶，即对新口味或食物的排斥，涉及到各种大脑区域的相互作用，包括中央味觉系统内的区域以及服务于其他功能的核团。以前的研究使用 c-Fos 成像技术，确定了几个在摄入新口味后比摄入熟悉口味时显示出更高活性的大脑区域。本研究将这一分析扩展到包括其他可能有助于引起味觉厌恶的神经回路的区域。我们的数据显示，在外侧杏仁核、杏仁核中央核、丘脑味觉部分、岛叶皮质味觉部分以及臂旁核的内侧和外侧区域，c-Fos 表达增加。这些结果证实了在摄入新口味时活跃的区域的贡献，并揭示了在这些条件下表达更高水平 c-Fos 的其他区域，从而增加了参与检测和初始处理味觉新奇性的神经网络。
