Ross J G, Halliday W G
J Helminthol. 1982 Mar;56(1):27-35. doi: 10.1017/s0022149x00034969.
Resistance to challenge infection with Trichostrongylus colubriformis was studied in an outbred strain of guinea-pigs. Resistance was conferred by previous infections of 50 or 100 infective larvae and by intraperitoneal, intramuscular and subcutaneous administration of dialysed transfer factor prepared from guniea-pigs infected with T. colubriformis, by intraperitoneal administration of transfer factor prepared from the blood of sheep infected with T. colubriformis and on one of three occasions using transfer factor prepared from guinea-pigs which had not been infected with T. colubriformis. No significant resistance was transferred by administration of antigen prepared from adult T. colubriformis, or by non-dialysed transfer factor, or by dialysed transfer factor prepared from T. colubriformis-infected guinea-pig tissue which had been stored for several months at - 20 degrees C.
在一个远交系豚鼠中研究了对蛇形毛圆线虫感染攻击的抵抗力。通过先前感染50或100条感染性幼虫，以及通过腹腔内、肌肉内和皮下注射从感染蛇形毛圆线虫的豚鼠制备的透析转移因子、腹腔内注射从感染蛇形毛圆线虫的绵羊血液制备的转移因子，以及在三次实验中的一次使用从未感染蛇形毛圆线虫的豚鼠制备的转移因子，可赋予抵抗力。通过注射从成年蛇形毛圆线虫制备的抗原、未透析的转移因子或从在-20℃下储存数月的感染蛇形毛圆线虫的豚鼠组织制备的透析转移因子，均未转移显著的抵抗力。
