Sebestík V, Kseliková M, Freiová M, Potmĕsilová I
Acta Biol Med Ger. 1978;37(1):127-30.
In experiments with "chemically splenectomized" rats by an i.v. application of ethyl palmitate (EP) emulsion and using [14C]-L-leucine, the protein synthesis in spleen and liver was followed. Two hours following EP application protein synthesis in the spleen was significantly decreased; after 24 hrs and 4 days the incorporation increased moderately above normal values, and in the subsequent intervals protein synthesis was again lowered. In the liver a significant increase of protein synthesis 24 hrs and 4 days after EP injection was observed. Changes of proteins synthesis in the spleen are evidently related to damage of the tissue and its subsequent regeneration. Changes in the liver are manifestations rather of an increased metabolic load during EP degradation.
在用静脉注射棕榈酸乙酯（EP）乳剂对大鼠进行“化学性脾切除”实验中，并使用[14C] - L - 亮氨酸，追踪了脾脏和肝脏中的蛋白质合成情况。注射EP两小时后，脾脏中的蛋白质合成显著下降；24小时和4天后，掺入量适度高于正常值，在随后的时间段内蛋白质合成再次降低。在肝脏中，注射EP后24小时和4天观察到蛋白质合成显著增加。脾脏中蛋白质合成的变化显然与组织损伤及其随后的再生有关。肝脏中的变化更多是EP降解过程中代谢负荷增加的表现。
