Kupchik E J, Pisano M A, Whalen S M, Lynch J
J Pharm Sci. 1982 Mar;71(3):311-4. doi: 10.1002/jps.2600710312.
Five triorganotin 5-nitro-2-furoates were synthesized by reacting 5-nitro-2-furoic acid with either the corresponding bis(triorganotin) oxide or the corresponding triorganotin hydroxide. The IR spectrum of each compound was obtained over the 4000--200-cm-1 range, and some of the bands were assigned. One compound, tri-n-butyltin 5-nitro-2-furoate, was an excellent antifungal agent, completely inhibiting the growth of six of ten test fungi at a concentration of 1 microgram/ml. The new compounds were also investigated for antibacterial activity and were especially inhibitory toward Gram-positive species. Two of the compounds completely inhibited the Gram-negative bacterium Escherichia coli at a concentration of 100 microgram/ml.
通过使5-硝基-2-呋喃甲酸与相应的双（三有机锡）氧化物或相应的三有机锡氢氧化物反应，合成了五种三有机锡5-硝基-2-呋喃甲酸酯。在4000 - 200厘米-1范围内获得了每种化合物的红外光谱，并对一些谱带进行了归属。一种化合物，三正丁基锡5-硝基-2-呋喃甲酸酯，是一种优异的抗真菌剂，在浓度为1微克/毫升时能完全抑制十种测试真菌中的六种的生长。还对这些新化合物的抗菌活性进行了研究，它们对革兰氏阳性菌特别有抑制作用。其中两种化合物在浓度为100微克/毫升时能完全抑制革兰氏阴性菌大肠杆菌。
