Kupchik E J, Pisano M A, Hanke H E, Tseng W C
J Pharm Sci. 1978 Apr;67(4):576-8. doi: 10.1002/jps.2600670442.
Five ethyl N-aryl-S-(triphenylstannyl)isothiocarbamates were synthesized by the reaction of triphenyltin iodide with the appropriate ethyl N-arylthiocarbamate in the presence of triethylamine. The IR spectrum of each compound was obtained over the 4000--200-cm--1 range, and some bands were assigned. These new compounds were found to be generally better antifungal agents than the previously tested N-substituted N'-cyano-S-(triphenylstannyl)isothioureas. The new compounds were also investigated for antibacterial activity and were especially inhibitory toward Gram-positive species. Except for their lower activity toward Bacillus subtilis, their antibacterial activity was identical to the previously tested N-phenyl-N'-cyano-S-(triphenylstannyl)isothiourea.
通过三苯基碘化锡与适当的N-芳基硫代氨基甲酸乙酯在三乙胺存在下反应，合成了五种N-芳基-S-（三苯基锡基）异硫代氨基甲酸乙酯。在4000 - 200 cm⁻¹范围内获得了每种化合物的红外光谱，并归属了一些谱带。发现这些新化合物通常比先前测试的N-取代的N'-氰基-S-（三苯基锡基）异硫脲是更好的抗真菌剂。还研究了这些新化合物的抗菌活性，它们对革兰氏阳性菌特别有抑制作用。除了对枯草芽孢杆菌活性较低外，它们的抗菌活性与先前测试的N-苯基-N'-氰基-S-（三苯基锡基）异硫脲相同。
