Genetics of teratocarcinoma transplantation. III. Genetic control of resistance to F9 tumor formation in allogeneic hosts.

Major F9 allograft resistance of strains C57Bl/6J, CBA/J, C3H/He and AKR/J has been shown to be controlled by a small number of recessive genes. These loci are not linked to H-2. Recombinational analysis suggests that the loci responsible for resistance in these strains are at least partially non-overlapping. These results obtained with the blocked F9 embryonal carcinoma cell line are discussed in relation to those reported for embryonal carcinoma strain PCC3/A/l and OTT6050 embryoid bodies, where recessive resistance is H-2 linked.