Grundy J E, Mackenzie J S, Stanley N F
Infect Immun. 1981 Apr;32(1):277-86. doi: 10.1128/iai.32.1.277-286.1981.
The resistance of adult mice to acute lethal infection with murine cytomegalovirus is controlled by genes linked to the H-2 complex. The k haplotype is approximately 10 times more resistant than the b or d haplotypes. Susceptibility is inherited as a completely dominant trait. At least two genes within the H-2 complex are involved, one mapping to the K/IA subregion and the other to the D subregion. The data suggest that interactions may occur between these K- and D-end genes which further affect resistance to the virus. The precise mechanism of H-2 gene control of resistance to murine cytomegalovirus remains to be elucidated. Non-H-2 linked genes also affect resistance to the virus, particularly in the C57BL genetic background, which is associated with an increased resistance to murine cytomegalovirus. Newborn mice of all strains are equally susceptible: both the H-2- and the non-H-2-associated resistances develop in the first few weeks of life and are retained up to at least 18 months of age.
成年小鼠对鼠巨细胞病毒急性致死性感染的抵抗力由与H-2复合体相关的基因控制。k单倍型的抵抗力比b或d单倍型高约10倍。易感性作为一种完全显性性状遗传。H-2复合体内至少有两个基因参与其中，一个定位于K/IA亚区，另一个定位于D亚区。数据表明，这些K端和D端基因之间可能发生相互作用，进而进一步影响对该病毒的抵抗力。H-2基因控制对鼠巨细胞病毒抵抗力的确切机制仍有待阐明。非H-2连锁基因也影响对该病毒的抵抗力，特别是在C57BL遗传背景中，该背景与对鼠巨细胞病毒抵抗力的增强有关。所有品系的新生小鼠同样易感：与H-2相关和与非H-2相关的抵抗力在出生后的头几周内形成，并至少维持到18个月龄。
