Lamers M C, de Groot E R, Roos D
Lab Invest. 1982 Apr;46(4):393-9.
DNA-anti-DNA complexes were prepared with igG anti-DNA or IgM anti-DNA and incubated with monocytes and neutrophils from human blood. The capacity of the complexes to induce phagocytosis and degradation of the antigen by the phagocytes varied with the composition of the complexes. Complexes prepared with IgG anti-DNA were readily processed (phagocytosed and degraded) by the cells, provided the complexes were large (precipitating at 3000 x g in 15 minutes). Processing of the complex required the Fc part of the IgG antibody. Complexes prepared with IgM anti-DNA were hardly processed at all, although they were as large as the IgG anti-DNA-containing complexes that were processed. IgM anti-DNA enhanced the processing of IgG anti-DNA-DNA complexes by increasing the size of the complexes.
用IgG抗DNA或IgM抗DNA制备DNA-抗DNA复合物，并与人血中的单核细胞和中性粒细胞一起孵育。复合物诱导吞噬细胞吞噬和降解抗原的能力随复合物的组成而变化。用IgG抗DNA制备的复合物很容易被细胞处理（吞噬和降解），前提是复合物较大（在3000×g下15分钟内沉淀）。复合物的处理需要IgG抗体的Fc部分。用IgM抗DNA制备的复合物几乎完全不被处理，尽管它们与被处理的含IgG抗DNA的复合物一样大。IgM抗DNA通过增加复合物的大小增强了IgG抗DNA-DNA复合物的处理。
