Stoner H B, Morris I D, Little R A, Hadfield J M, Marshall H W, Yarker Y E
Neuropharmacology. 1982 Mar;21(3):221-5. doi: 10.1016/0028-3908(82)90191-5.
The finding that naloxone reverses the arterial hypotension produced by bacterial endotoxin in the rat was confirmed and the effect of naloxone on the responses to another form of injury, limb ischaemia was studied. Naloxone had no effect on the fall in blood pressure and colon temperature or on behaviour and survival after bilateral hind-limb ischaemia. The ambient temperature threshold for the onset of shivering was depressed by limb ischaemia as in untreated rats. The increases in the plasma concentrations of glucose and corticosterone and the decrease in that of prolactin after limb ischaemia were unaltered by naloxone. In control rats naloxone reduced the ambient temperature threshold for the onset of shivering and the plasma prolactin concentration. It is concluded that the endogenous opioids do not play a very significant part in the responses to ischaemic limb trauma.
纳洛酮可逆转大鼠体内细菌内毒素所致动脉低血压这一发现得到了证实，并且研究了纳洛酮对另一种损伤形式即肢体缺血反应的影响。纳洛酮对双侧后肢缺血后的血压下降、结肠温度或行为及存活情况均无影响。与未治疗的大鼠一样，肢体缺血使寒颤开始时的环境温度阈值降低。纳洛酮未改变肢体缺血后血浆葡萄糖和皮质酮浓度的升高以及催乳素浓度的降低。在对照大鼠中，纳洛酮降低了寒颤开始时的环境温度阈值以及血浆催乳素浓度。得出的结论是，内源性阿片类物质在对缺血性肢体创伤的反应中不起非常重要的作用。
