Pazo J H, Medina J H, Tumilasci O R
Neuropharmacology. 1982 Mar;21(3):261-5. doi: 10.1016/0028-3908(82)90196-4.
Experiments were performed in rats of the Wistar strain anesthetized with alpha-chloralose (100 mg/kg). Electrolytic lesion of either components of the striopallidal complex (corpus striatum, globus pallidus or entopeduncular nucleus) reduced the sensory response to L-DOPA in the contralateral submaxillary glands. Damage to other neural structures, directly or indirectly related to the striopallidal system, left the salivary response unaffected. These structures were: substantia nigra, cerebral cortex, ventromedial and center median-parafascicular thalamic nuclei, nucleus accumbens and posterior hypothalamic areas, including the medial forebrain bundle and lateral habenular nucleus. However, lesions placed in H1-H2 fields of Forel and reticular formation, lateral to the periaqueductal gray, reduced the salivary response in the contralateral glands. This effect was similar to that observed in animals with lesions of the striopallidal complex. From this study, it is concluded that the striatum is the target area for the central effect of L-DOPA on salivary secretion, by activation of pathways descending through the fields of Forel and mesencephalic reticular formation to the contralateral lower brain stem.
实验在以α-氯醛糖（100毫克/千克）麻醉的Wistar品系大鼠身上进行。纹状体苍白球复合体（纹状体、苍白球或内苍白球核）任何一个组分的电解损伤都会降低对侧颌下腺对左旋多巴的感觉反应。对与纹状体苍白球系统直接或间接相关的其他神经结构的损伤，不会影响唾液反应。这些结构包括：黑质、大脑皮层、腹内侧和丘脑中央中核-束旁核、伏隔核以及下丘脑后部区域，包括内侧前脑束和外侧缰核。然而，在导水管周围灰质外侧的Forel H1-H2区和网状结构中的损伤，会降低对侧腺体的唾液反应。这种效应与纹状体苍白球复合体损伤的动物中观察到的效应相似。从这项研究可以得出结论，纹状体是左旋多巴对唾液分泌产生中枢效应的靶区域，通过激活经Forel区和中脑网状结构下行至对侧低位脑干的通路来实现。
