Rengachary S S, Tomita T, Jefferies B F, Watanabe I
Neurosurgery. 1982 Feb;10(2):242-51.
The histological appearance of a prolactin-producing tumor and of a growth hormone-producing tumor after short term bromocriptine therapy was studied in detail using light microscopy with conventional and immunocytochemical methods and using transmission electron microscopy. The findings were correlated with clinical, radiological, and biochemical data. Histological changes consisting of clumping of nuclear chromatin and a marked reduction in cytoplasmic volume due to loss of ribosomes, rough endoplasmic reticulum, and Golgi complexes were observed only in the prolactin-producing tumor. Normalization of elevated serum prolactin levels and reduction in size of the tumor observed in serial computed tomograms correlated with striking histological changes found in the tumor. These changes were interpreted to represent a reversible inhibition of the protein-synthetic machinery of the neoplastic cell. Comparable clinical, biochemical, radiological, or structural changes were not observed in the growth hormone-secreting tumor.
采用常规和免疫细胞化学方法的光学显微镜以及透射电子显微镜，对短期使用溴隐亭治疗后的催乳素分泌瘤和生长激素分泌瘤的组织学表现进行了详细研究。研究结果与临床、放射学和生化数据相关联。仅在催乳素分泌瘤中观察到由核染色质聚集以及由于核糖体、粗面内质网和高尔基体复合物丢失导致的细胞质体积显著减少所组成的组织学变化。在连续计算机断层扫描中观察到血清催乳素水平升高的正常化以及肿瘤大小的减小，这与肿瘤中发现的显著组织学变化相关。这些变化被解释为代表肿瘤细胞蛋白质合成机制的可逆性抑制。在生长激素分泌瘤中未观察到类似的临床、生化、放射学或结构变化。
