Glennon R A, Young R, Rosecrans J A
Pharmacol Biochem Behav. 1982 Apr;16(4):557-9. doi: 10.1016/0091-3057(82)90414-2.
Twenty-four rats, trained to discriminate 1.0 mg/kg of (+/-)-DOM, i.e. (+/-)-2,5-dimethoxy-4-methylphenylisopropylamine, from saline under a VI-15 schedule of reinforcement, were challenged with a series of DOM homologs. The agents examined included the 4-ethyl (DOET), -propyl (DOPR), -butyl (DOBU), -tertiary butyl (DOTB) and -amyl (DOAM) derivatives as well as the R(-)- and S(+)-isomers of DOET. The (+/-)-DOM stimulus was found to generalize to all of the agents, except DOTB and DOAM, where only partial generalization occurred. The results suggest that the stimulus properties produced by the latter two compounds may differ from those of the remainder of the series. Furthermore, the ED50 values obtained, for those compounds to which the DOM-stimulus generalized, correlated significantly (r2 = 0.94) with the human hallucinogenic potencies of these agents.
24只经过训练，能在固定间隔15秒强化程序下从盐水中辨别出1.0毫克/千克（±）-DOM（即（±）-2,5-二甲氧基-4-甲基苯异丙胺）的大鼠，接受了一系列DOM同系物的挑战。所检测的药物包括4-乙基（DOET）、-丙基（DOPR）、-丁基（DOBU）、-叔丁基（DOTB）和-戊基（DOAM）衍生物，以及DOET的R（-）-和S（+）-异构体。发现（±）-DOM刺激能泛化到所有药物，但DOTB和DOAM除外，在DOTB和DOAM中仅出现部分泛化。结果表明，后两种化合物产生的刺激特性可能与该系列其余化合物不同。此外，对于DOM刺激能泛化的那些化合物，所获得的半数有效剂量（ED50）值与这些药物的人体致幻效力显著相关（r2 = 0.94）。
