Milam K M, Stern J S, Horwitz B A
Pharmacol Biochem Behav. 1982 Apr;16(4):627-30. doi: 10.1016/0091-3057(82)90427-0.
To test nonshivering thermogenic (NST) capacity of lean and obese Zucker rats, 4 doses of isoproterenol, ranging in concentration from 0.25 to 6.0 micrograms/min . kg . 75, were intravenously infused into 16 to 18 week old male rats, and oxygen consumption was continuously monitored. Obese rats had a decreased NST response relative to lean littermates. This lowered thermogenic response of the obese rats cannot be attributed to a decreased mass of brown adipose tissue since both the cervical and interscapular depots from obese rats weighed significantly more than did those from lean rats.
为了测试瘦型和肥胖型 Zucker 大鼠的非颤抖性产热（NST）能力，将 4 种浓度范围为 0.25 至 6.0 微克/分钟·千克·75 的异丙肾上腺素静脉注射到 16 至 18 周龄的雄性大鼠体内，并持续监测耗氧量。相对于瘦型同窝仔鼠，肥胖大鼠的 NST 反应降低。肥胖大鼠这种降低的产热反应不能归因于棕色脂肪组织量的减少，因为肥胖大鼠的颈部和肩胛间脂肪库重量明显高于瘦型大鼠。
