多发性硬化症中的脑脊液C2与HLA系统

Cerebro spinal fluid C2 and HLA system in multiple sclerosis.

作者信息

Delasnerie-Laupretre N, Suet-Hubert C, Marcelli-Barge A

出版信息

Tissue Antigens. 1982 Jan;19(1):79-84. doi: 10.1111/j.1399-0039.1982.tb01418.x.

DOI:10.1111/j.1399-0039.1982.tb01418.x

Abstract

C3 hemolytic activity has been measured in serum and C.S.F. of 67 multiple sclerosis (M.S.) patients classified in three evolutionary groups according to the index of progression of the disease and tested in HLA-A, B, C, DR and Bf. The median level of serum C2 is normal whether it is of the evolution or the HLA type. The average level of C.S.F. C2 is the same in the evolutionary groups and is low in patients bearing B 18 allele or B 18, DR2 haplotype. It seems that the median level of C.S.F. C2 is linked to the HLA types associated to the susceptibility gene(s) of the disease.

摘要

已对67例多发性硬化症（MS）患者的血清和脑脊液中的C3溶血活性进行了测量，这些患者根据疾病进展指数分为三个进展组，并进行了HLA - A、B、C、DR和Bf检测。无论处于疾病进展阶段还是HLA类型如何，血清C2的中位数水平均正常。脑脊液C2的平均水平在各进展组中相同，而携带B18等位基因或B18、DR2单倍型的患者中该水平较低。似乎脑脊液C2的中位数水平与与该疾病易感基因相关的HLA类型有关。