Dupuy G M, Roberts K D, Bleau G, Chapdelaine A
Steroids. 1982 Feb;39(2):201-19. doi: 10.1016/0039-128x(82)90087-3.
The interconversion and extraction of estrone and estradiol-17beta across and within different tissues or areas have been studied in the dog by the constant infusion technique. The results were calculated estradiol obtained from afferent and efferent blood and tissues at equilibrium. From these results it is concluded that: (1) there is no significant difference between metabolic clearance rates of estrone and estradiol, (2) blood transfer constants indicates a higher conversion of estradiol to estrone than of estrone to estradiol, (3) the transtissue interconversion favors the formation of estrone while the intratissue interconversion favors the formation of estradiol, (4) no interconversion of the two estrogens is observed in adipose tissue, (5) the extraction of estradiol entering a tissue was lower than the extraction of estradiol formed in these tissues, (6) calculation of the tissue metabolic clearance rates show that 63% of the total metabolism of estrone and estradiol, respectively, occurs in the splanchnic bed, and (7) the contribution of each tissues to the total interconversion of estrone and estradiol show that more than 90% of this interconversion occurs extrahepatically.
采用持续输注技术，在犬体内研究了雌酮与雌二醇 - 17β在不同组织或区域之间以及组织内部的相互转化和提取情况。通过计算平衡状态下从传入和传出血液及组织中获得的雌二醇得出结果。根据这些结果得出以下结论：（1）雌酮和雌二醇的代谢清除率无显著差异；（2）血液转移常数表明，雌二醇向雌酮的转化高于雌酮向雌二醇的转化；（3）跨组织相互转化有利于雌酮的形成，而组织内相互转化有利于雌二醇的形成；（4）在脂肪组织中未观察到两种雌激素的相互转化；（5）进入组织的雌二醇的提取率低于这些组织中形成的雌二醇 的提取率；（6）组织代谢清除率的计算表明，雌酮和雌二醇的总代谢分别有 63%发生在内脏床；（7）各组织对雌酮和雌二醇总相互转化的贡献表明，这种相互转化的 90%以上发生在肝外。
