Paulsen S M, Nielsen V T, Hansen P, Ferenczy A
Ultrastruct Pathol. 1982 Jan-Mar;3(1):31-42. doi: 10.3109/01913128209016623.
A case of low grade endometrial stromal sarcoma with tubular-glandular differentiation is reported. The tumor showed a characteristic pattern of clusters and trabeculae of spindle-shaped cells infiltrating the myometrium. Lymphatic invasion was evident. Foci of solid, alveolar pattern and cleft tubular spaces were seen. The tubular spaces were lined by a cuboidal epithelium, which at the ultrastructural level showed blunt microvilli, and between adjacent cells junctional complexes and desmosomes. Both the spindle-shaped cells and the epithelial cells were rich in cytoplasmic filaments. The latter did not react with serum containing antibody against actin using a two-layer immunoperoxidase method. The ultrastructural resemblance between the epithelial and spindle-shaped cells favors a common cellular origin, the endometrial stromal fibroblast.
报告一例具有管状腺分化的低级别子宫内膜间质肉瘤。肿瘤呈现出梭形细胞簇和小梁的特征性模式，浸润子宫肌层。可见明显的淋巴血管浸润。存在实性、肺泡样结构灶和裂隙状管状间隙。管状间隙内衬立方上皮，在超微结构水平显示钝圆微绒毛，相邻细胞间有连接复合体和桥粒。梭形细胞和上皮细胞的胞质中均富含细丝。使用双层免疫过氧化物酶法，后者与含抗肌动蛋白抗体的血清不发生反应。上皮细胞和梭形细胞在超微结构上的相似性支持它们具有共同的细胞起源，即子宫内膜间质成纤维细胞。
