Spangler W L, Waring G O, Morrin L A
Vet Pathol. 1982 Mar;19(2):150-9. doi: 10.1177/030098588201900206.
Naturally occurring, oval opacities at the junction of the middle and inferior thirds of the cornea were found in an experimental beagle dog colony and were examined by light and electron microscopy. Abnormalities were limited to the anterior stroma and consisted of extracellular rhomboid crystalline spaces. Spherical or elliptical vacuolar spaces, sometimes containing electron-dense amorphous debris, distorted stromal lamellae. Stromal keratocytes in affected areas revealed a range of changes from hyperplasia of organelles to degeneration and necrosis.
在一个实验性比格犬群体中发现角膜中下部交界处有自然出现的椭圆形混浊，并通过光学显微镜和电子显微镜进行了检查。异常仅限于前基质，由细胞外菱形晶体间隙组成。球形或椭圆形的空泡间隙，有时含有电子致密的无定形碎片，使基质板层变形。受影响区域的基质角膜细胞显示出一系列变化，从细胞器增生到变性和坏死。
