MacMillan A D, Waring G O, Spangler W L, Roth A M
J Am Vet Med Assoc. 1979 Oct 15;175(8):829-32.
Bilaterally symmetric opacities were detected in the corneal stroma of 78 (14%) of 560 Siberian Huskies, aged 7 months to 12 years, examined in ophthalmology screening clinics. The opacities were round or horizontally oval and consisted of a diffuse gray homogeneous haze in the anterior stroma or an array of fine polychromatic crystals in the posterior stroma, or both. The corneas were not inflamed. The frequency of occurrence and density of the opacities increased with age. Several affected dogs were closely related, but a specific inheritance pattern could not be established. Light and electron microscopy disclosed clusters of extracellular, thin, needle-shaped, crystalline clefts. Histochemical stains on frozen sections identified neutral fats, phospholipids, and cholesterol as components of the crystals.
在眼科筛查诊所接受检查的560只年龄在7个月至12岁之间的西伯利亚哈士奇中，有78只（14%）在角膜基质中检测到双侧对称的混浊。混浊呈圆形或水平椭圆形，由前基质中的弥漫性灰色均匀薄雾或后基质中的一系列细小多色晶体组成，或两者皆有。角膜未发炎。混浊的发生率和密度随年龄增长而增加。几只患病犬有密切的亲缘关系，但无法确定具体的遗传模式。光镜和电镜检查发现细胞外有成群的薄针状晶体裂隙。对冰冻切片进行组织化学染色，确定中性脂肪、磷脂和胆固醇为晶体的成分。
