甲型流感病毒在犬肾传代细胞（MDCK）中的冷适应重组体。I. A/安阿伯/6/60 X A/阿拉斯加/6/77重组病毒的构建与特性分析 - Suppr

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超能文献

Cold-adapted recombinants of influenza A virus in MDCK cells. I. Development and characterization of A/Ann Arbor/6/60 X A/Alaska/6/77 recombinant viruses.

作者信息

Odagiri T, DeBorde D C, Maassab H F

出版信息

Virology. 1982 May;119(1):82-95. doi: 10.1016/0042-6822(82)90067-8.

DOI:10.1016/0042-6822(82)90067-8

PMID:7072155

Abstract

摘要

相似文献

Cold-adapted recombinants of influenza A virus in MDCK cells. I. Development and characterization of A/Ann Arbor/6/60 X A/Alaska/6/77 recombinant viruses.甲型流感病毒在犬肾传代细胞（MDCK）中的冷适应重组体。I. A/安阿伯/6/60 X A/阿拉斯加/6/77重组病毒的构建与特性分析

Virology. 1982 May;119(1):82-95. doi: 10.1016/0042-6822(82)90067-8.

Comparative studies of wild-type and 'cold-mutant' (temperature sensitive) influenza viruses: geneology of the matrix (M) and non-structural (NS) proteins in recombinant cold-adapted H3N2 viruses.野生型和“冷突变型”（温度敏感型）流感病毒的比较研究：重组冷适应H3N2病毒中基质（M）蛋白和非结构（NS）蛋白的谱系

J Gen Virol. 1977 Oct;37(1):145-59. doi: 10.1099/0022-1317-37-1-145.

Characterization of the temperature sensitive phenotype of the A/Ann Arbor/6/60 cold-adapted virus and its recombinants.A/安阿伯/6/60冷适应病毒及其重组体温度敏感表型的特征分析。

Infect Immun. 1981 May;32(2):960-3. doi: 10.1128/iai.32.2.960-963.1981.

Comparative studies of wild-type and cold-mutant (temperature-sensitive) influenza viruses: independent segregation of temperature-sensitivity of virus replication from temperature-sensitivity of virion transcriptase activity during recombination of mutant A/Ann Arbor/6/60 with wild-type H3N2 strains.野生型和冷突变（温度敏感型）流感病毒的比较研究：在突变株A/安阿伯/6/60与野生型H3N2毒株重组过程中，病毒复制的温度敏感性与病毒粒子转录酶活性的温度敏感性独立分离。

J Gen Virol. 1979 Aug;44(2):443-56. doi: 10.1099/0022-1317-44-2-443.

Evaluation of A/Alaska/6/77 (H3N2) cold-adapted recombinant viruses derived from A/Ann Arbor/6/60 cold-adapted donor virus in adult seronegative volunteers.在成年血清阴性志愿者中对源自A/安阿伯/6/60冷适应供体病毒的A/阿拉斯加/6/77（H3N2）冷适应重组病毒进行评估。

Infect Immun. 1981 May;32(2):693-7. doi: 10.1128/iai.32.2.693-697.1981.

Biological, genetic and biochemical characterization of a cold-adapted recombinant A/Victoria/3/75 virus and its evaluation in volunteers.一种冷适应重组A/维多利亚/3/75病毒的生物学、遗传学和生物化学特性及其在志愿者中的评估。

Dev Biol Stand. 1977;39:25-31.

Genetic stability of A/Ann Arbor/6/60 cold-mutant (temperature-sensitive) live influenza virus genes: analysis by oligonucleotide mapping of recombinant vaccine strains before and after replication in volunteers.A/安阿伯/6/60冷突变株（温度敏感型）活流感病毒基因的遗传稳定性：通过对志愿者体内复制前后重组疫苗株的寡核苷酸图谱分析。

J Infect Dis. 1984 Feb;149(2):194-200. doi: 10.1093/infdis/149.2.194.

[Molecular genetic analysis of a cold-adapted donor attenuation strain for a pediatric liver influenza vaccine, of recombinants based on it and of isolates from vaccinated children].[用于儿科肝脏流感疫苗的冷适应供体减毒株、基于该减毒株的重组体以及接种疫苗儿童分离株的分子遗传分析]

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Comparative studies of wild-type and cold-mutant (temperature-sensitive) influenza viruses: nonrandom reassortment of genes during preparation of live virus vaccine candidates by recombination at 25 degrees between recent H3N2 and H1N1 epidemic strains and cold-adapted A/An Arbor/6/60.野生型和冷突变（温度敏感型）流感病毒的比较研究：在25摄氏度下，通过近期H3N2和H1N1流行毒株与冷适应的A/安阿伯/6/60株之间的重组制备活病毒候选疫苗期间基因的非随机重配。

Virology. 1979 Aug;97(1):190-4. doi: 10.1016/0042-6822(79)90386-6.

Cold-adapted reassortants of influenza A virus: pathogenicity of A/Ann Arbor/6/60 X A/Alaska/6/77 reassortant viruses in vivo and in vitro.

Arch Virol. 1986;91(1-2):53-60. doi: 10.1007/BF01316727.

引用本文的文献

A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.一个突变的 PB1 残基 319 与活减毒流感疫苗中的 PB2 N265S 突变协同作用，赋予了温度敏感性。

Viruses. 2020 Oct 31;12(11):1246. doi: 10.3390/v12111246.

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Sci Rep. 2016 Jul 26;6:30382. doi: 10.1038/srep30382.

Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers.甲型流感病毒冷适应重配活疫苗CR-37（H1N1）在日本成年志愿者中的血清学评估。

J Hyg (Lond). 1984 Apr;92(2):231-42. doi: 10.1017/s0022172400064251.

Analysis of an influenza A virus mutant with a deletion in the NS segment.对一种NS片段存在缺失的甲型流感病毒突变体的分析。

J Virol. 1984 Feb;49(2):418-25. doi: 10.1128/JVI.49.2.418-425.1984.

Attenuation of wild-type human influenza A virus by acquisition of the PA polymerase and matrix protein genes of influenza A/Ann Arbor/6/60 cold-adapted donor virus.通过获取甲型流感病毒/安阿伯/6/60冷适应供体病毒的PA聚合酶基因和基质蛋白基因来减毒野生型人类甲型流感病毒。

J Clin Microbiol. 1985 Nov;22(5):719-25. doi: 10.1128/jcm.22.5.719-725.1985.

Cold-adapted reassortants of influenza A virus: pathogenicity of A/Ann Arbor/6/60 X A/Alaska/6/77 reassortant viruses in vivo and in vitro.

Arch Virol. 1986;91(1-2):53-60. doi: 10.1007/BF01316727.

Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines.四种病毒基因独立促成了甲型流感病毒/安阿伯/6/60（H2N2）冷适应重配病毒活疫苗的减毒。

J Virol. 1988 Feb;62(2):488-95. doi: 10.1128/JVI.62.2.488-495.1988.

Evaluation of cold-recombinant influenza A/Korea (CR-59) virus vaccine in infants.婴儿中冷重组甲型/韩国（CR-59）流感病毒疫苗的评估。

J Clin Microbiol. 1989 May;27(5):909-14. doi: 10.1128/jcm.27.5.909-914.1989.

Biological characteristics of a cold-adapted influenza A virus mutation residing on a polymerase gene.一种存在于聚合酶基因上的冷适应甲型流感病毒突变体的生物学特性

Arch Virol. 1986;88(1-2):91-104. doi: 10.1007/BF01310893.

Mutation in NS2, a nonstructural protein of influenza A virus, extragenically causes aberrant replication and expression of the PA gene and leads to generation of defective interfering particles.甲型流感病毒的非结构蛋白NS2发生突变，会在基因外导致PA基因异常复制和表达，并导致产生缺陷干扰颗粒。

Proc Natl Acad Sci U S A. 1990 Aug;87(15):5988-92. doi: 10.1073/pnas.87.15.5988.

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