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一种遗传性红细胞特征,NOR,可导致红细胞多凝集。

An inherited RBC characteristic, NOR, resulting in erythrocyte polyagglutination.

作者信息

Harris P A, Roman G K, Moulds J J, Bird G W, Shah N G

出版信息

Vox Sang. 1982 Mar;42(3):134-40. doi: 10.1111/j.1423-0410.1982.tb01083.x.

DOI:10.1111/j.1423-0410.1982.tb01083.x
PMID:7072192
Abstract

This report describes a new inheritable red blood cell characteristic, termed NOR, that is associated with polyagglutination. The NOR factor was shown to be inherited in an apparent dominant manner by 5 members of a two-generation family. NOR was clearly demonstrated to be a unique form of polyagglutination distinguishable from previously reported forms by serological tests using seed lectins, snail agglutinins, enzymes and absorption techniques. The NOR factor was characterized by the lack of reactivity with various seed and snail lectins, enhanced serum agglutinability after RBC proteolytic enzyme treatment, and the ability of hydatid cyst fluid to inhibit the serum hemagglutination reaction.

摘要

本报告描述了一种新的可遗传红细胞特征,称为NOR,它与多凝集反应相关。在一个两代家庭的5名成员中,NOR因子显示以明显的显性方式遗传。通过使用种子凝集素、蜗牛凝集素、酶和吸收技术的血清学检测,NOR被明确证明是一种独特的多凝集反应形式,与先前报道的形式不同。NOR因子的特征是与各种种子和蜗牛凝集素缺乏反应性,红细胞经蛋白水解酶处理后血清凝集性增强,以及棘球蚴囊液能够抑制血清血凝反应。

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1
An inherited RBC characteristic, NOR, resulting in erythrocyte polyagglutination.一种遗传性红细胞特征,NOR,可导致红细胞多凝集。
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A single point mutation in the gene encoding Gb3/CD77 synthase causes a rare inherited polyagglutination syndrome.基因编码 Gb3/CD77 合酶的单点突变导致一种罕见的遗传性多凝集综合征。
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