Kober G, Klepzig H, Kaltenbach M
Z Kardiol. 1982 Jan;71(2):102-5.
This study was done to substantiate the observation that there is a high coincidence of predominant left coronary circulations in patients with valvular aortic stenoses, Between 1973 and 1980, 506 patients, who underwent coronary angiography and ventriculography, were investigated: patients with mitral stenosis (group I; n = 77), mitral regurgitation and combined mitral valve dysfunction (group II; n = 50), aortic regurgitation with or without mitral valve disease (group III; n = 61), pure aortic stenosis (group IV; n = 49) and the combination of aortic stenosis and insufficiency with mitral valve disease group V; n = 69). Patients with coronary heart disease (group 6; n = 200) served as control. Predominant left circulation was present in a comparable frequency in the valve-patient group 1 (8%), group 2 (10%) and group 3 (8%) and with patients with coronary heart disease (7.5%). A distinctly higher frequency was observed in group 4 (33%; p less than 0.001) and in group 5 (19%; p less than 0.01). We conclude that valvular aortic stenosis and predominant left coronary circulation might have the same genetic or developmental background.
本研究旨在证实瓣膜性主动脉瓣狭窄患者中左冠状动脉占优势的循环情况具有高度一致性。1973年至1980年间，对506例行冠状动脉造影和心室造影的患者进行了调查：二尖瓣狭窄患者（第一组；n = 77）、二尖瓣反流及二尖瓣联合瓣膜功能障碍患者（第二组；n = 50）、伴或不伴二尖瓣疾病的主动脉瓣反流患者（第三组；n = 61）、单纯主动脉瓣狭窄患者（第四组；n = 49）以及主动脉瓣狭窄与关闭不全合并二尖瓣疾病患者（第五组；n = 69）。冠心病患者（第六组；n = 200）作为对照。第一组瓣膜病患者（8%）、第二组（10%）、第三组（8%）以及冠心病患者（7.5%）中左冠状动脉占优势的循环出现频率相当。第四组（33%；p<0.001）和第五组（19%；p<0.01）中观察到的频率明显更高。我们得出结论，瓣膜性主动脉瓣狭窄与左冠状动脉占优势的循环可能具有相同的遗传或发育背景。
