Shefer V F
Zh Nevropatol Psikhiatr Im S S Korsakova. 1982;82(2):236-40.
The numbers of senile plaques, neurofibrillar bundles, and neurofibrillar "skeletons" in a certain constant volume of the left temporal pole cortex were calculated in 131 psychically healthy subjects who died at an age of 41 to 101 years, and in 111 subjects who suffered at lifetime from debilitating diseases of the type of senile dementia (dotage) and Alzheimer's disease. Each senile plaque was estimated at 0.1 point, and each neurofibrillar bundle and neurofibrillar "skeleton" at 1.0 point. In each case the points were summed up. In 86% of the cases of senile dementia and Alzheimer's disease the total of the points exceeded the maxima found in the psychically healthy subjects. This gives one grounds to recommend this method for making reliable pathoanatomic diagnoses of debilitating diseases of the type of senile dementia or Alzheimer's disease.
对131名年龄在41至101岁之间自然死亡的心理健康受试者，以及111名一生中患有老年痴呆（衰老）和阿尔茨海默病等衰弱性疾病的受试者，计算其左颞极皮质一定恒定体积内的老年斑、神经原纤维束和神经原纤维“骨架”数量。每个老年斑计0.1分，每个神经原纤维束和神经原纤维“骨架”计1.0分。每种情况都将分数相加。在86%的老年痴呆和阿尔茨海默病病例中，总分超过了心理健康受试者中的最高值。这使人们有理由推荐这种方法用于对老年痴呆或阿尔茨海默病等衰弱性疾病进行可靠的病理解剖诊断。
