Chan D, Fox N C, Scahill R I, Crum W R, Whitwell J L, Leschziner G, Rossor A M, Stevens J M, Cipolotti L, Rossor M N
Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK.
Ann Neurol. 2001 Apr;49(4):433-42.
Volumetric magnetic resonance imaging analyses of 30 subjects were undertaken to quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's disease. Three groups of 10 subjects were studied: semantic dementia patients, Alzheimer's disease patients, and control subjects. The temporal lobe structures measured were the amygdala, hippocampus, entorhinal cortex, parahippocampal gyrus, fusiform gyrus, and superior, middle, and inferior temporal gyri. Semantic dementia and Alzheimer's disease groups did not differ significantly on global atrophy measures. In semantic dementia, there was asymmetrical temporal lobe atrophy, with greater left-sided damage. There was an anteroposterior gradient in the distribution of temporal lobe atrophy, with more marked atrophy anteriorly. All left anterior temporal lobe structures were affected in semantic dementia, with the entorhinal cortex, amygdala, middle and inferior temporal gyri, and fusiform gyrus the most severely damaged. Asymmetrical, predominantly anterior hippocampal atrophy was also present. In Alzheimer's disease, there was symmetrical atrophy of the entorhinal cortex, hippocampus, and amygdala, with no evidence of an anteroposterior gradient in the distribution of temporal lobe or hippocampal atrophy. These data demonstrate that there is a marked difference in the distribution of temporal lobe atrophy in semantic dementia and Alzheimer's disease. In addition, the pattern of atrophy in semantic dementia suggests that semantic memory is subserved by anterior temporal lobe structures, within which the middle and inferior temporal gyri may play a key role.
对30名受试者进行了容积磁共振成像分析，以量化语义性痴呆和阿尔茨海默病患者的全脑及颞叶萎缩情况。研究对象分为三组，每组10人：语义性痴呆患者、阿尔茨海默病患者和对照受试者。所测量的颞叶结构包括杏仁核、海马体、内嗅皮质、海马旁回、梭状回以及颞上回、颞中回和颞下回。语义性痴呆组和阿尔茨海默病组在全脑萎缩测量方面无显著差异。在语义性痴呆中，存在不对称的颞叶萎缩，左侧损伤更严重。颞叶萎缩分布存在前后梯度，前部萎缩更明显。语义性痴呆患者的所有左侧颞叶前部结构均受影响，其中内嗅皮质、杏仁核、颞中回和颞下回以及梭状回受损最严重。还存在不对称的、主要为前部的海马萎缩。在阿尔茨海默病中，内嗅皮质、海马体和杏仁核存在对称性萎缩，颞叶或海马萎缩分布无前后梯度迹象。这些数据表明，语义性痴呆和阿尔茨海默病在颞叶萎缩分布上存在显著差异。此外，语义性痴呆的萎缩模式表明，语义记忆由颞叶前部结构支持，其中颞中回和颞下回可能起关键作用。
