Orskov H, Hansen A P, Hansen H E, Alberti K G, Noy G A, Nosadini R
Acta Endocrinol (Copenh). 1982 Apr;99(4):551-8. doi: 10.1530/acta.0.0990551.
Five diabetic and 14 non-diabetic uraemic patients on long-term haemodialysis were studied during twenty-one 24 h periods including 5 to 7 h of haemodialysis against glucose-free acetate buffered dialysis fluid. Half-hourly blood samples were collected for hormonal and metabolite analysis. In addition, blood samples were analyzed in 40 experiments covering the haemodialysis and a pre-dialysis period. Before dialysis, plasma growth hormone levels were high and fluctuating, but almost always fell to low normal values within the first 2 h of haemodialysis. In the diabetic uraemic patients, the occasional severe hypoglycaemic episodes occurring during haemodialysis did not provoke growth hormone release, and hypoglycaemic reactions were not encountered. Intravenous acetate infusion studies resulted in plasma concentrations ranging from 1.3. to 2.7 mmol, ie. about 60 per cent of the levels reached during haemodialysis and in suppression of growth hormone secretion. It is suggested that the fall in growth hormone levels and the lack of hypoglycaemic symptoms during haemodialysis is due to the use of acetate as a fuel in brain.
对5名糖尿病和14名非糖尿病的长期血液透析尿毒症患者进行了研究，研究为期21个24小时时段，其中包括使用无糖醋酸盐缓冲透析液进行5至7小时的血液透析。每半小时采集一次血样进行激素和代谢物分析。此外，在40项涵盖血液透析和透析前阶段的实验中对血样进行了分析。透析前，血浆生长激素水平较高且波动较大，但几乎总是在血液透析的前2小时内降至低正常水平。在糖尿病尿毒症患者中，血液透析期间偶尔发生的严重低血糖发作并未引发生长激素释放，也未出现低血糖反应。静脉输注醋酸盐的研究结果显示，血浆浓度范围为1.3至2.7 mmol，即约为血液透析期间达到水平的60%，且生长激素分泌受到抑制。有人认为，血液透析期间生长激素水平下降以及缺乏低血糖症状是由于大脑将醋酸盐用作燃料所致。
