醋酸盐抑制尿毒症患者生长激素分泌：血液透析和醋酸盐输注实验

Acetate suppresses growth hormone secretion in uremic patients: hemodialysis and acetate infusion experiments.

作者信息

Schmitz O, Hansen A P, Hansen H E, Orskov H, Alberti K G

出版信息

Artif Organs. 1982 May;6(2):132-5. doi: 10.1111/j.1525-1594.1982.tb04074.x.

DOI:10.1111/j.1525-1594.1982.tb04074.x

Abstract

Growth hormone secretion in uremic patients is completely suppressed immediately after initiation of and during hemodialysis using acetate dialysate. The present study demonstrates that growth hormone secretion stimulated by arginine is also inhibited by hemodialysis. Acetate infusion experiments proved that the high blood acetate level obtained during dialysis is at least partly responsible for this growth hormone suppression by unknown mechanisms.

摘要

使用醋酸盐透析液进行血液透析开始后及透析期间，尿毒症患者的生长激素分泌会立即受到完全抑制。本研究表明，精氨酸刺激的生长激素分泌也会受到血液透析的抑制。醋酸盐输注实验证明，透析期间出现的高血醋酸盐水平至少部分是通过未知机制导致这种生长激素抑制的原因。