Kamei T, Ishihara T, Fujihara S, Nakamura H, Yokota T, Imada N, Akizuki S, Iwata T, Uchino F
Acta Pathol Jpn. 1982 Jan;32(1):123-33. doi: 10.1111/j.1440-1827.1982.tb02033.x.
Clinical and pathological findings are reported in a Japanese girl who died of secondary amyloidosis associated with juvenile rheumatoid arthritis two years after the onset of symptoms. The patient had intermittent high fever, rheumatoid rash, polyarthralgia, and hepatosplenomegaly. The joints showed the typical histologic changes of juvenile rheumatoid arthritis. Amyloid deposition was found in various tissues; however, remarkable deposition of amyloid was observed in the gastrointestinal tract, especially in the ileum. The amyloid protein in this patient was identified as protein AA using the methods of potassium permanganate treatment and the peroxidase-antiperoxidase unlabeled antibody technique.
报告了一名日本女孩的临床和病理检查结果，该女孩在症状出现两年后死于与青少年类风湿性关节炎相关的继发性淀粉样变性。患者有间歇性高热、类风湿皮疹、多关节痛和肝脾肿大。关节表现出青少年类风湿性关节炎的典型组织学变化。在各种组织中均发现了淀粉样蛋白沉积；然而，在胃肠道，尤其是回肠中观察到了显著的淀粉样蛋白沉积。使用高锰酸钾处理方法和过氧化物酶-抗过氧化物酶未标记抗体技术，将该患者的淀粉样蛋白鉴定为AA蛋白。
