Kavukçu S, Türkmen M, Saatçi O, Başdemir G, Gülay Z, Cevik N T
Department of Paediatrics, Dokuz Eylül University, Faculty of Medicine, Inciralti, Izmir, Turkey.
Int Urol Nephrol. 1995;27(3):251-6. doi: 10.1007/BF02564758.
Clinical renal abnormalities, including haematuria, proteinuria, abnormal urinary sediment, decreased renal functions and hypertension are relatively common in children with juvenile rheumatoid arthritis (JRA). These findings may be due to renal amyloidosis or administration of drugs that are potentially nephrotoxic. The case of an 11 years old boy diagnosed as JRA at 4.5 months of age and treated with steroids for 10 years is presented. In his history he had hypertension for 5 years and cataract for one year. Renal biopsy was done to evaluate the aetiology for proteinuria, which was overlooked before his admission to our Department. Secondary renal amyloidosis due to JRA was found at biopsy. The importance of investigation for amyloidosis during the long-term follow-up of JRA is reemphasized.
临床肾脏异常，包括血尿、蛋白尿、异常尿沉渣、肾功能减退和高血压，在幼年类风湿关节炎（JRA）患儿中相对常见。这些表现可能是由于肾淀粉样变性或使用了具有潜在肾毒性的药物。本文报告了一名11岁男孩的病例，他在4.5个月大时被诊断为JRA，并接受了10年的类固醇治疗。他有5年高血压病史和1年白内障病史。为评估蛋白尿的病因进行了肾活检，蛋白尿在他入院前被忽视。活检发现继发于JRA的肾淀粉样变性。再次强调了在JRA长期随访中对淀粉样变性进行检查的重要性。
