Jackson R T, Latham M C
Am J Clin Nutr. 1982 Apr;35(4):710-4. doi: 10.1093/ajcn/35.4.710.
Research was conducted in Liberia, West Africa to ascertain which hematinics produce the best Hb response in women during the 3rd trimester of pregnancy. After obtaining background information, each of the 621 subjects was randomly assigned to one of four treatment groups. Group 1 was given 60 mg iron once daily, group 2 was given 60 mg iron 3 times daily, group 3 was given 60 mg iron 3 times daily plus a 5-mg folic acid tablet once daily, and group 4 was given the same treatment as group 3 but also a weekly antimalarial prophylactic. For comparison, 58 untreated women in their 3rd trimester were also studied. Before therapy the five groups were similar with respect to selected socioeconomic status, health, and dietary variables. Hb response to therapy was measured at 4-wk intervals from the 24th wk of gestation until term. The Hb rises in all four treatment groups were significantly (p less than 0.001) higher than the base-line values at 4, 8, and 12 wk after the interventions. The percentage of anemic women was reduced from 78 to 45% over the 12 wk of supplementation. Hb rises in groups 3 and 4 were not significantly different from those in groups receiving iron alone. It is concluded that iron deficiency is the main cause of anemia in this population.
在西非的利比里亚开展了一项研究，以确定哪些补血剂能使孕期第三个月的女性血红蛋白（Hb）反应最佳。在获取背景信息后，621名受试者中的每一位都被随机分配到四个治疗组之一。第1组每天服用一次60毫克铁剂，第2组每天服用三次60毫克铁剂，第3组每天服用三次60毫克铁剂加一片5毫克叶酸片，第4组接受与第3组相同的治疗，但还每周进行一次疟疾预防。作为对照，还对58名处于孕期第三个月的未接受治疗的女性进行了研究。在治疗前，五组在选定的社会经济地位、健康和饮食变量方面相似。从妊娠第24周直到足月，每隔4周测量一次治疗后的血红蛋白反应。在干预后的第4、8和12周，所有四个治疗组的血红蛋白升高均显著高于基线值（p<0.001）。在补充的12周内，贫血女性的比例从78%降至45%。第3组和第4组的血红蛋白升高与仅接受铁剂治疗的组没有显著差异。得出的结论是，缺铁是该人群贫血的主要原因。
