McKinley M J, Troncale F, Sangree M H, Scholhamer C, Brand M
Am J Gastroenterol. 1982 Feb;77(2):77-81.
Antibiotic-associated colitis is known to occur with temporal and geographic clustering. During 1979 a marked increase in the incidence of this disease was noted at our institutions. The clinical, epidemiological, and endoscopic features are reported. Typical features included the acute onset of watery diarrhea, fever, abdominal pain, tenderness, and the presence of leukocytosis. Epidemiological data revealed a nosocomial pattern of this illness and a striking female predominance. Two-thirds of the patients had an underlying gynecological or urological disorder. Dysuria and sterile pyuria were unexpected findings. It is suggested that the organism responsible for this disease may be hospital acquired and associated with underlying genitourinary disorders.
已知抗生素相关性结肠炎会出现时间和地域聚集性。1979年期间，我们机构注意到这种疾病的发病率显著上升。本文报告了其临床、流行病学及内镜特征。典型特征包括水样腹泻、发热、腹痛、压痛及白细胞增多症的急性发作。流行病学数据显示该疾病呈医院感染模式，且女性占比显著。三分之二的患者患有潜在的妇科或泌尿系统疾病。排尿困难和无菌性脓尿是意外发现。提示引起该疾病的病原体可能是医院获得性的，且与潜在的泌尿生殖系统疾病有关。
