Stergachis A, Perera D R, Schnell M M, Jick H
West J Med. 1984 Feb;140(2):217-9.
We determined the incidence of antibiotic-associated colitis among users of oral antibiotics or topical clindamycin in a large prepaid health plan. Exposure to antibiotics was determined using a system that automatically records outpatient prescriptions filled and hospital diagnoses were available from computer files. Four cases of acute colitis were judged likely to be causally linked with outpatient use of antibiotics. These findings provide substantial evidence that antibiotic-associated colitis requiring hospital treatment occurs very rarely.
我们在一个大型预付健康计划中确定了口服抗生素或外用克林霉素使用者中抗生素相关性结肠炎的发病率。使用一个自动记录门诊药房配药情况的系统来确定抗生素暴露情况，并且可以从计算机文件中获取医院诊断信息。有4例急性结肠炎被判定可能与门诊使用抗生素有因果关系。这些发现提供了充分的证据表明需要住院治疗的抗生素相关性结肠炎非常罕见。
