米诺环素在兔实验性眼弓形虫病中的应用
Minocycline in experimental ocular toxoplasmosis in the rabbit.
作者信息
Rollins D F, Tabbara K F, Ghosheh R, Nozik R A
出版信息
Am J Ophthalmol. 1982 Mar;93(3):361-5. doi: 10.1016/0002-9394(82)90541-4.
We studied the effects of minocycline, a semisynthetic tetracycline, on experimentally induced toxoplasmic retinochoroiditis in the rabbit. In two experiments we found that this drug effectively ameliorated the clinical disease and sterilized the ocular tissues from Toxoplasma organisms. Minocycline prevented death from toxoplasmic encephalitis in 75% of the animals, whereas all the control animals died of toxoplasmic encephalitis. Minocycline appears to be a promising agent for ocular toxoplasmosis.
我们研究了半合成四环素米诺环素对兔实验性诱导的弓形体性视网膜脉络膜炎的影响。在两项实验中，我们发现这种药物有效地改善了临床疾病，并使眼部组织中的弓形虫生物体失活。米诺环素使75%的动物免于死于弓形体性脑炎，而所有对照动物均死于弓形体性脑炎。米诺环素似乎是一种治疗眼部弓形体病的有前景的药物。
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