Tabbara K F, Sakuragi S, O'Connor G R
Parasitology. 1982 Apr;84(Pt 2):297-302. doi: 10.1017/s0031182000044851.
The effects of minocycline alone or in combination with sulphadiazine were evaluated against acute murine toxoplasmosis and compared with the efficacy of pyrimethamine and sulphadiazine. The date presented show that mice could be protected from acute toxoplasmosis by minocycline, in spite of using a virulent strain of Toxoplasma gondii, a large inoculum, and a delay in the administration of the drug. Acute toxoplasmic infection in mice could be eradicated by aminocycline--sulphadiazine combination, which was found to be as effective as pyrimethamine--sulphadiazine combination therapy.
评估了米诺环素单独使用或与磺胺嘧啶联合使用对急性小鼠弓形虫病的效果，并与乙胺嘧啶和磺胺嘧啶的疗效进行了比较。所呈现的数据表明，尽管使用了强毒株弓形虫、大剂量接种物且药物给药延迟，但米诺环素仍可保护小鼠免受急性弓形虫病的侵害。米诺环素 - 磺胺嘧啶联合用药可根除小鼠的急性弓形虫感染，发现其效果与乙胺嘧啶 - 磺胺嘧啶联合疗法相同。
