Wendling P, Füssinger R, Schmidt H D, Stosseck K
Anaesthesist. 1982 Mar;31(3):135-8.
The validity of transcutaneous oxygen partial pressure (tcPO2) was tested during pharmacological vasodilatation and vasoconstriction of the skin. Measurements of transcutaneous oxygen partial pressure (tcPO2) were done on the hairless skin of the abdomen in 18 anaesthetized rabbits, when beta-pyridyl-carbonyl (Ronicol) was used as a vasodilator and vasopressin (Pitressin) as a vasoconstrictor. Vasodilation yielded no significant influence on the tcPO2-measurement. Vasoconstriction, however, resulted in a marked decrease of the tcPO2-signal (p less than 0.001). During this phase tcPO2 did no longer reflect arterial PO2 which remained nearly constant. In this experimental model vasoconstrictive drugs may cause a marked underestimation of the arterial oxygen tension. The dependence of the tcPO2-measurement on maximal local skin perfusion should be considered in intensive care patients.
在皮肤进行药理学血管舒张和血管收缩期间，对经皮氧分压（tcPO2）的有效性进行了测试。在18只麻醉兔的腹部无毛皮肤上测量经皮氧分压（tcPO2），使用β-吡啶羰基（Ronicol）作为血管舒张剂，血管加压素（Pitressin）作为血管收缩剂。血管舒张对tcPO2测量没有显著影响。然而，血管收缩导致tcPO2信号显著降低（p<0.001）。在此阶段，tcPO2不再反映几乎保持恒定的动脉血氧分压。在这个实验模型中，血管收缩药物可能会导致对动脉氧张力的显著低估。在重症监护患者中应考虑tcPO2测量对最大局部皮肤灌注的依赖性。
