Frisbie D D, Kawcak C E, Baxter G M, Trotter G W, Powers B E, Lassen E D, McIlwraith C W
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
Am J Vet Res. 1998 Dec;59(12):1619-28.
To determine effects of intra-articularly administered 6alpha-methylprednisolone acetate (MPA) in exercised horses with carpal osteochondral fragmentation.
18 horses: 3 groups of 6 each.
An osteochondral (chip) fragment was created in 1 randomly chosen middle carpal joint of each horse. Polyionic fluid (PF) was injected into both middle carpal joints of horses in the control group. In horses of the MPA-control group, MPA was injected into the middle carpal joint without an osteochondral fragment; a similar volume of PF was injected into the contralateral middle carpal joint. In the MPA-treated group of horses, 100 mg of MPA was injected into the middle carpal joint containing the osteochondral fragment; a similar volume of PF was injected into the contralateral joint. Injections were administered on postsurgical days 14 and 28, and horses were exercised on a high-speed treadmill for 8 weeks, starting on postsurgical day 15.
Clinical improvement in degree of lameness was not associated with MPA administration. Joints that contained an osteochondral fragment and were treated with MPA had lower prostaglandin E2 concentration in synovial fluid, and lower scores for intimal hyperplasia and vascularity in synovial membrane, compared with PF-treated joints. However, articular cartilage erosion and morphologic lesions suggested possible deleterious effect of intra-articular MPA administration.
Some beneficial effects of MPA administration on synovial fluid and synovial membrane were identified; however, the deleterious findings contrast with those associated with triamcinolone acetonide used in a similar model, but agree with other results of MPA administration in normal and abnormal joints.
确定关节内注射醋酸6α-甲基泼尼松龙（MPA）对患有腕关节骨软骨碎裂的运动马匹的影响。
18匹马，分为3组，每组6匹。
在每匹马随机选择的1个腕中间关节制造1个骨软骨（碎片）。对照组马匹的双侧腕中间关节均注射聚离子液体（PF）。MPA对照组的马匹，在没有骨软骨碎片的腕中间关节注射MPA；对侧腕中间关节注射相同体积的PF。MPA治疗组的马匹，在含有骨软骨碎片的腕中间关节注射100mg MPA；对侧关节注射相同体积的PF。在术后第14天和第28天进行注射，从术后第15天开始，马匹在高速跑步机上运动8周。
跛行程度的临床改善与MPA给药无关。与PF治疗的关节相比，含有骨软骨碎片且接受MPA治疗的关节，其滑液中前列腺素E2浓度较低，滑膜内膜增生和血管化评分较低。然而，关节软骨侵蚀和形态学病变提示关节内注射MPA可能具有有害作用。
确定了MPA给药对滑液和滑膜有一些有益作用；然而，有害结果与在类似模型中使用曲安奈德的结果相反，但与MPA在正常和异常关节给药的其他结果一致。
