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绵羊外周血和输出淋巴淋巴细胞的丝裂原诱导的母细胞化

Mitogen-induced blastogenesis of peripheral blood and efferent lymph lymphocytes from sheep.

作者信息

Fiscus S A, DeMartini J C, Pearson L D

出版信息

Am J Vet Res. 1982 Apr;43(4):629-32.

PMID:7073085
Abstract

Peripheral blood lymphocytes and efferent lymph lymphocytes (ELL) from 20 healthy adult sheep were studied for their blastogenic responses to the phytolectins concanavalin A, phytohemagglutinin, and pokeweed mitogen. Peripheral blood lymphocytes generally incorporated significantly (P less than 0.00001) more [3H]thymidine than did ELL. The lower response in ELL, especially in concanavalin A- and pokeweed mitogen-stimulated cultures, may be due to an insufficiency of accessory cells that may be required for optimal proliferation.

摘要

对20只健康成年绵羊的外周血淋巴细胞和传出淋巴淋巴细胞(ELL)进行了研究,以观察它们对植物凝集素刀豆球蛋白A、植物血凝素和商陆有丝分裂原的增殖反应。外周血淋巴细胞通常比ELL掺入显著更多(P<0.00001)的[3H]胸腺嘧啶核苷。ELL较低的反应,尤其是在刀豆球蛋白A和商陆有丝分裂原刺激的培养物中,可能是由于最佳增殖所需的辅助细胞不足。

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