Baron M, Lee P, Keystone E C
Ann Rheum Dis. 1982 Apr;41(2):147-52. doi: 10.1136/ard.41.2.147.
The articular manifestations of progressive systemic sclerosis (PSS) were studied in 38 patients. Of these, 66% experienced joint pain and 61% had signs of joint inflammation. Limitation of joint movement was seen in 45%. Radiological abnormalities included periarticular osteoporosis (42%), joint space narrowing (34%), and erosions (40%). Erosive disease did not correlate with disease duration, presence of rheumatoid factor, antinuclear antibodies, distal tuft resorption, or the extent of the scleroderma skin changes. Calcinosis was seen more frequently in those patients with articular erosions (67%). Erosive osteoarthritis of the distal interphalangeal joints (7 patients) was associated with impaired finger flexion. Joint involvement in PSS occurs frequently and may resemble rheumatoid arthritis in the early stages but is less destructive. The occurrence of unrelated arthropathy, such as primary osteoarthritis, is not uncommon, and its differentiation from true PSS joint disease can be difficult.
对38例进行性系统性硬化症（PSS）患者的关节表现进行了研究。其中，66%的患者经历过关节疼痛，61%有关节炎症体征。45%的患者出现关节活动受限。放射学异常包括关节周围骨质疏松（42%）、关节间隙变窄（34%）和侵蚀（40%）。侵蚀性疾病与病程、类风湿因子、抗核抗体、指端吸收或硬皮病皮肤改变的程度无关。钙质沉着在有关节侵蚀的患者中更常见（67%）。远端指间关节的侵蚀性骨关节炎（7例患者）与手指屈曲功能受损有关。PSS患者关节受累很常见，早期可能类似类风湿关节炎，但破坏性较小。不相关的关节病，如原发性骨关节炎的发生并不少见，将其与真正的PSS关节疾病区分开来可能很困难。
