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锂对大鼠电休克诱发惊厥的作用与其在脑和血浆中浓度的相关性。

Correlation of lithium effect on electroshock-induced seizure in rats with its concentration in brain and plasma.

作者信息

Roy U, Mukherjee B P

出版信息

Arch Int Pharmacodyn Ther. 1982 Jan;255(1):81-8.

PMID:7073401
Abstract

Effects of graded doses of lithium chloride (2.5, 5.0 and 7.5 mEq/kg, i.p.) on electroshock-induced seizure threshold, recovery time and concentration of lithium (Li) ion in plasma and brain tissue of albino rats, at different post injection intervals, were investigated. A significant decrease in seizure susceptibility corresponded with high Li ion concentration at 4 to 8 hr post injection period in the rat brain tissue.

摘要

研究了不同注射后间隔时间,分级剂量的氯化锂(2.5、5.0和7.5毫当量/千克,腹腔注射)对白化大鼠电击诱发惊厥阈值、恢复时间以及血浆和脑组织中锂离子浓度的影响。在大鼠脑组织注射后4至8小时期间,惊厥易感性的显著降低与高锂离子浓度相对应。

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