Mehls O, Ritz E, Gilli G, Wangdak T, Krempien B
Am J Clin Nutr. 1978 Oct;31(10):1927-31. doi: 10.1093/ajcn/31.10.1927.
Acceleration of growth of uremic children after administration of vitamin D has been demonstrated by various authors. This has been attributed to healing of skeletal lesions. Clinical observations suggest that vitamin D has also an effect on food intake perhaps associated with improvement of vitality. This could be confirmed in an experimental study in which uremic rats (subtotal nephrectomy) with and without vitamin D supplementation were compared with sham-operated pair-fed control rats with and without vitamin D supplementation. In uremic animals supplemented with vitamin D, weight gain and growth were significantly greater than in uremic animals on the control diet. Both with and without vitamin D supplements, weight gain and growth rate were greater in sham-operated pair-fed control than in the corresponding uremic animals. Histological abnormalities in the growth zone of uremic rats were markedly reduced by vitamin D. Since food intake was greater in vitamin D-treated uremic animals than in nonvitamin D-treated uremic animals, the increase in growth rate under vitamin D cannot be attributed exclusively to the skeletal effects of vitamin D. This study demonstrates important extraskeletal actions of vitamin D which may be associated with or causally related to the improvement of growth.
多位作者已证实，给予维生素D后尿毒症患儿的生长加速。这归因于骨骼病变的愈合。临床观察表明，维生素D对食物摄入量也有影响，可能与活力改善有关。这在一项实验研究中得到了证实，该研究将补充和未补充维生素D的尿毒症大鼠（次全肾切除术）与补充和未补充维生素D的假手术配对喂养对照大鼠进行了比较。在补充维生素D的尿毒症动物中，体重增加和生长明显大于对照饮食的尿毒症动物。无论是否补充维生素D，假手术配对喂养对照大鼠的体重增加和生长速度均高于相应的尿毒症动物。维生素D显著减轻了尿毒症大鼠生长区的组织学异常。由于接受维生素D治疗的尿毒症动物的食物摄入量高于未接受维生素D治疗的尿毒症动物，维生素D作用下生长速度的增加不能完全归因于维生素D对骨骼的影响。这项研究证明了维生素D重要的骨骼外作用，这些作用可能与生长改善相关或存在因果关系。
