Kolycheva N I, Fedotovskiikh G V, Aleksandrova N M, Zumerov E L
Arkh Patol. 1982;44(2):34-41.
Electron microscopic examinations of the ultrastructure of normal esophageal epithelium of an adult man revealed submicroscopic features of each epithelial layer. A specific structure of epithelial cells is represented by tonofibrils. Glycogen is found only in the prickle-cell and superficial layers. In the latter there were some signs of incomplete keratinization. Hyperplasia of the prickle-cell and superficial layers epithelium was accompanied by accumulation of glycogen and marked parakeratosis with disintegration of the nucleus, formation of keratin fibrils, and destruction of desmosomal bonds. Dysplastic changes in the esophageal epithelium were heterogenous and presented a whole set of ultrastructural rearrangements. We distinguish two variants of dysplasia. In the "dark-cell" variant there were hypertrophy and hyperchromia of the nucleus, deep invaginations of the nuclear membrane, swelling of the mitochondria, appearance of myelin-like structures in the matrix, increased number of free ribosomes, polysomes, and lipids, formation of tonofibrillar-keratohyaline complexes, increased number of cytoplasmic processes. The "clear-cell" variant was characterized by nuclear hypertrophy, marked dilation of cisterns of the rough endoplasmic reticulum, extensive vesicle formation, keratohyaline granules, few cytoplasmic outgrowths, dilation of the intercellular space.
对一名成年男性正常食管上皮超微结构的电子显微镜检查揭示了各上皮层的亚微观特征。上皮细胞的一种特定结构由张力原纤维表示。糖原仅在棘细胞层和表层中发现。在表层有一些不完全角化的迹象。棘细胞层和表层上皮的增生伴随着糖原的积累以及明显的不全角化，伴有细胞核解体、角蛋白原纤维形成和桥粒连接破坏。食管上皮的发育异常变化是异质性的，并呈现出一整套超微结构重排。我们区分两种发育异常变体。在“暗细胞”变体中，细胞核肥大、核膜深陷、线粒体肿胀、基质中出现髓鞘样结构、游离核糖体、多核糖体和脂质数量增加、张力原纤维 - 透明角质颗粒复合物形成、细胞质突起数量增加。“透明细胞”变体的特征是细胞核肥大、粗面内质网池明显扩张、广泛的囊泡形成、透明角质颗粒、少量细胞质突起、细胞间隙扩张。
