Fedotovskikh G V, Kolycheva N I
Vopr Onkol. 1987;33(10):38-43.
Dysplasia foci in the esophageal squamous epithelium against the background of various reactions of proliferation were studied by electron microscopy. Slightly altered tissue showed diverse cellularity, with dark cambial elements invariably present. With dysplasia advancing, the cell composition became uniform, with a high nuclear-cytoplasmic index. The dark cell pattern with numerous ribosomes was seen more often than that of keratinized clear cells. Small-cell focal proliferations are highly suggestive of precancer. Electron microscopy may be instrumental in eliciting more information on the risk of esophageal squamous epithelium precancer progressing to cancer since it provides data on cell composition, degree of cell differentiation and polysome formation as well as early signs of keratinization.
通过电子显微镜研究了食管鳞状上皮发育异常病灶，其背景为各种增殖反应。轻度改变的组织显示细胞多样性，始终存在深色的形成层成分。随着发育异常进展，细胞组成变得均匀，核质指数高。可见具有大量核糖体的暗细胞模式比角化透明细胞模式更常见。小细胞灶性增殖强烈提示癌前病变。电子显微镜可能有助于获取更多关于食管鳞状上皮癌前病变进展为癌症风险的信息，因为它提供了细胞组成、细胞分化程度、多核糖体形成的数据以及角化的早期迹象。
