Tremoli E, Ghiselli G, Maderna P, Colli S, Sirtori C R
Atherosclerosis. 1982 Jan;41(1):53-60. doi: 10.1016/0021-9150(82)90069-7.
The effects of Metformin treatment on platelet responsiveness to aggregating agents was studied in cholesterol-fed rabbits. Three groups of animals were fed, for one month, either a normal (N), or a hypercholesterolemic (HC), or a hypercholesterolemic + 0.5% Metformin diet (HC + Met), Platelets from the HC rabbits required significantly lower collagen and arachidonic acid concentrations to aggregate, as compared to platelets from N rabbits. The platelet response from the HC + Met rabbits was not significantly different from that of normals. The cholesterol/phospholipid ratio in platelets was increased in both dietary groups (HC, HC + Met). The serum thromboxane B2 concentrations did not show any significant difference between the groups. Plasma exchange experiments failed to indicate a specific effect of the plasma environment on platelet behaviour. In view of the inactivity of metformin on the platelet cyclo-oxygenase pathway, the reported results suggest that metformin may act by an as yet unexplored mechanism.
在喂食胆固醇的兔子身上研究了二甲双胍治疗对血小板对聚集剂反应性的影响。将三组动物分别喂食正常（N）、高胆固醇（HC）或高胆固醇 + 0.5%二甲双胍饮食（HC + Met）一个月。与N组兔子的血小板相比，HC组兔子的血小板聚集所需的胶原蛋白和花生四烯酸浓度显著更低。HC + Met组兔子的血小板反应与正常组无显著差异。两个饮食组（HC、HC + Met）的血小板中胆固醇/磷脂比率均升高。各组之间血清血栓素B2浓度无显著差异。血浆置换实验未能表明血浆环境对血小板行为有特定影响。鉴于二甲双胍对血小板环氧化酶途径无活性，所报道的结果表明二甲双胍可能通过一种尚未探索的机制起作用。
