高胆固醇血症兔血小板中血栓素B2的生物合成及磷脂水解

Thromboxane B2 biosynthesis and phospholipids hydrolysis in platelets from hypercholesterolemic rabbits.

作者信息

Kawaguchi H, Ishibashi T, Imai Y

出版信息

Lipids. 1981 Jan;16(1):37-42. doi: 10.1007/BF02534919.

PMID:7219079

Abstract

Thromboxane B2 biosynthesis from arachidonic acid was increased in platelets from hypercholesterolemic rabbits. The enzymic activity of phospholipase A2 which releases arachidonic acid, the precursor for the biosynthesis of thromboxane B2, showed hardly any change in hypercholesterolemic platelets. Phospholipase C and diglyceride lipase activities also were not changed in platelets from hypercholesterolemic rabbits. Furthermore, phospholipid concentration in platelets were not increased in this state. Thus, we conclude that the supply of precursor for thromboxane B2 biosynthesis was not increased in platelets from hypercholesterolemic rabbits as compared to controls. These results suggest that the enzyme activity of thromboxane B2 biosynthesis may be enhanced in platelets from hypercholesterolemic rabbits.

摘要

高胆固醇血症兔血小板中，由花生四烯酸合成血栓素B2的过程增强。释放花生四烯酸（血栓素B2生物合成的前体）的磷脂酶A2的酶活性，在高胆固醇血症血小板中几乎没有变化。磷脂酶C和甘油二酯脂肪酶的活性在高胆固醇血症兔的血小板中也没有改变。此外，在此状态下血小板中的磷脂浓度没有增加。因此，我们得出结论，与对照组相比，高胆固醇血症兔血小板中血栓素B2生物合成的前体供应没有增加。这些结果表明，高胆固醇血症兔血小板中血栓素B2生物合成的酶活性可能增强。