Loutit J F, Townsend K M
Br J Exp Pathol. 1982 Apr;63(2):221-3.
Beige mice, osteopetrotic from incorporated mi/mi genes, and their skeletally normal siblings were X-irradiated and converted to radiation chimaeras by rescue with normal CBA bone marrow. The procedure produced rapid cure of the osteopetrosis. Electron micrographic measurement of the decline in giant lysosomes of the host mice indicated that the longevity of the host's osteoclasts was up to 30 days in the osteopetrotic and 40 days in the skeletally normal mice. In each case the decline was roughly exponential with half-times of about 6 and 8 days respectively. Monogenetic and perhaps polygenetic and teleological factors are invoked. Absence of a latent period before decline in the score seen in the companion paper is attributed to the presence of partially mature osteoclast precursors in bone marrow, not present in spleen.
由于整合了mi/mi基因而患骨石化症的米色小鼠及其骨骼正常的同窝小鼠接受了X射线照射，并通过用正常CBA骨髓进行挽救而转化为辐射嵌合体。该程序使骨石化症迅速治愈。对宿主小鼠巨大溶酶体减少的电子显微镜测量表明，骨石化小鼠中宿主破骨细胞的寿命长达30天，骨骼正常的小鼠中为40天。在每种情况下，减少大致呈指数形式，半衰期分别约为6天和8天。文中提到了单基因以及可能的多基因和目的论因素。在 companion paper中观察到的分数下降之前没有潜伏期，这归因于骨髓中存在部分成熟的破骨细胞前体，而脾脏中不存在这种前体。
